Role of DNA methylation in miR-200c/141 cluster silencing in invasive breast cancer cells

@inproceedings{Neves2010RoleOD,
  title={Role of DNA methylation in miR-200c/141 cluster silencing in invasive breast cancer cells},
  author={Rui Neves and Christina Scheel and Sandra Weinhold and Ellen Honisch and Katharina M. Iwaniuk and Hans-Ingo Trompeter and D Niederacher and Peter Wernet and Simeon Santourlidis and Markus Uhrberg},
  booktitle={BMC Research Notes},
  year={2010}
}
The miR-200c/141 cluster has recently been implicated in the epithelial to mesenchymal transition (EMT) process. The expression of these two miRNAs is inversely correlated with tumorigenicity and invasiveness in several human cancers. The role of these miRNAs in cancer progression is based in part on their capacity to target the EMT activators ZEB1 and ZEB2, two transcription factors, which in turn repress expression of E-cadherin. Little is known about the regulation of the mir200c/141 cluster… CONTINUE READING

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