Role of DNA intercalation in the inhibition of purified mouse leukemia (L1210) DNA topoisomerase II by 9-aminoacridines.

@article{Pommier1987RoleOD,
  title={Role of DNA intercalation in the inhibition of purified mouse leukemia (L1210) DNA topoisomerase II by 9-aminoacridines.},
  author={Yves Pommier and Joseph M. Covey and Deanna Kerrigan and W. B. Mattes and Judith Markovits and Kurt W. Kohn},
  journal={Biochemical pharmacology},
  year={1987},
  volume={36 20},
  pages={3477-86}
}
An attempt was made to analyze the mechanism by which 4'-(9-acridinylamino)methanesulfon-m-anisidide (m-AMSA) inhibits mammalian DNA topoisomerase II. The effects of various 9-aminoacridine derivatives differing by their DNA affinities and DNA sequence selectivity of binding were compared in the presence of purified mouse leukemia L1210 DNA topoisomerase II… CONTINUE READING