Role of DNA damage and epigenetic DNA methylation changes in radiation-induced genomic instability and bystander effects in germline in vivo.

@article{Tamminga2011RoleOD,
  title={Role of DNA damage and epigenetic DNA methylation changes in radiation-induced genomic instability and bystander effects in germline in vivo.},
  author={Jan Tamminga and Olga Kovalchuk},
  journal={Current molecular pharmacology},
  year={2011},
  volume={4 2},
  pages={115-25}
}
Ionizing radiation (IR) is a curative treatment for many human malignancies, an important diagnostic modality, and a pivotal preparative regimen for bone marrow transplantation. On the other hand, IR is a potent damaging agent that can affect a variety of processes in directly exposed cells, in their descendents, and in neighboring un-irradiated naïve 'bystander' cells. Accumulation of DNA damage caused by IR in conjunction with disrupted cellular regulation processes can lead to genome… CONTINUE READING

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