Role of DNA bubble rewinding in enzymatic transcription termination.

  title={Role of DNA bubble rewinding in enzymatic transcription termination.},
  author={Joo-Seop Park and Jeffrey W. Roberts},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={103 13},
By using DNA heteroduplexes that inhibit rewinding of the upstream part of the transcription bubble, we show that transcript release in termination by the enzymes Mfd and Rho is facilitated by reannealing of DNA in the upstream region of the transcription bubble, as is also true for termination by intrinsic terminators. We also show that, like Mfd, the Rho termination factor promotes forward translocation of RNA polymerase. These results support termination models in which external forces… CONTINUE READING
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