Role of DNA Methylation in the Regulation of Lipogenic Glycerol-3-Phosphate Acyltransferase 1 Gene Expression in the Mouse Neonatal Liver

@inproceedings{Ehara2012RoleOD,
  title={Role of DNA Methylation in the Regulation of Lipogenic Glycerol-3-Phosphate Acyltransferase 1 Gene Expression in the Mouse Neonatal Liver},
  author={Tatsuya Ehara and Yasutomi Kamei and Mayumi Takahashi and Xunmei Yuan and Sayaka Kanai and Erina Tamura and Miyako Tanaka and Tomomi Yamazaki and Shinji Miura and Osamu Ezaki and Takayoshi Suganami and Masaki Okano and Yoshihiro Ogawa},
  booktitle={Diabetes},
  year={2012}
}
The liver is a major organ of lipid metabolism, which is markedly changed in response to physiological nutritional demand; however, the regulation of hepatic lipogenic gene expression in early life is largely unknown. In this study, we show that expression of glycerol-3-phosphate acyltransferase 1 (GPAT1; Gpam), a rate-limiting enzyme of triglyceride biosynthesis, is regulated in the mouse liver by DNA methylation, an epigenetic modification involved in the regulation of a diverse range of… CONTINUE READING
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