Role of DDR1 in the gelatinases secretion induced by native type IV collagen in MDA-MB-231 breast cancer cells

@article{CastroSnchez2011RoleOD,
  title={Role of DDR1 in the gelatinases secretion induced by native type IV collagen in MDA-MB-231 breast cancer cells},
  author={Luis A Castro-S{\'a}nchez and Adriana Soto-Guzm{\'a}n and Margarita Guaderrama-D{\'i}az and Pedro Cort{\'e}s-Reynosa and Eduardo Perez Salazar},
  journal={Clinical & Experimental Metastasis},
  year={2011},
  volume={28},
  pages={463-477}
}
Discoidin domain receptors (DDRs) are receptor tyrosine kinases that get activated by collagens in its native triple-helical form. In mammalian cells, DDR family consists of two members, namely DDR1 and DDR2, which mediates migration and proliferation of several cell types. DDR1 is activated by native type IV collagen and overexpressed in human breast cancer. Type IV collagen is the main component of basement membrane (BM), and the ability to degrade and penetrate BM is related with an… CONTINUE READING

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Matrix metalloproteinases ( MMPs ) are a family of zinc - dependent endopeptidases that collectively are capable of degrading all components of the extracellular matrix , including the BM .
Matrix metalloproteinases ( MMPs ) are a family of zinc - dependent endopeptidases that collectively are capable of degrading all components of the extracellular matrix , including the BM .
Matrix metalloproteinases ( MMPs ) are a family of zinc - dependent endopeptidases that collectively are capable of degrading all components of the extracellular matrix , including the BM .
Discoidin domain receptors ( DDRs ) are receptor tyrosine kinases that get activated by collagens in its native triple - helical form .
Matrix metalloproteinases ( MMPs ) are a family of zinc - dependent endopeptidases that collectively are capable of degrading all components of the extracellular matrix , including the BM .
DDR1 wt AlleleGene associated with diseaseMammary Neoplasms
In summary , our data demonstrate , for the first time , that DDR1 mediates MMP-2 and -9 secretions and invasion induced by native type IV collagen in MDA - MB-231 breast cancer cells .
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