Role of DDAH-1 in lipid peroxidation product-mediated inhibition of endothelial NO generation.

@article{Pope2007RoleOD,
  title={Role of DDAH-1 in lipid peroxidation product-mediated inhibition of endothelial NO generation.},
  author={Arthur J Pope and Lawrence J. Druhan and Jorge E Guzman and Scott P Forbes and Velayutham Murugesan and Deqin Lu and Yong Xia and Louis G. Chicoine and Narasimham L. Parinandi and Arturo J. Cardounel},
  journal={American journal of physiology. Cell physiology},
  year={2007},
  volume={293 5},
  pages={C1679-86}
}
Altered nitric oxide (NO) biosynthesis is thought to play a role in the initiation and progression of atherosclerosis and may contribute to increased risk seen in other cardiovascular diseases. It is hypothesized that altered NO bioavailability may result from an increase in endogenous NO synthase (NOS) inhibitors, asymmetric dimethly araginine (ADMA), and N(G)-monomethyl arginine, which are normally metabolized by dimethyarginine dimethylamine hydrolase (DDAH). Lipid hydroperoxides and their… CONTINUE READING
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