Role of Cytosolic Phospholipase A2 in Oxidative and Inflammatory Signaling Pathways in Different Cell Types in the Central Nervous System

@article{Sun2014RoleOC,
  title={Role of Cytosolic Phospholipase A2 in Oxidative and Inflammatory Signaling Pathways in Different Cell Types in the Central Nervous System},
  author={Grace Y Sun and Dennis Yi-Lun Chuang and Yijia Zong and Jinghua Jiang and James Michael Lee and Zezong Gu and Agnes Simonyi},
  journal={Molecular Neurobiology},
  year={2014},
  volume={50},
  pages={6-14}
}
Phospholipases A2 (PLA2s) are important enzymes for the metabolism of fatty acids in membrane phospholipids. Among the three major classes of PLA2s in the mammalian system, the group IV calcium-dependent cytosolic PLA2 alpha (cPLA2α) has received the most attention because it is widely expressed in nearly all mammalian cells and its active participation in cell metabolism. Besides Ca2+ binding to its C2 domain, this enzyme can undergo a number of cell-specific post-translational modifications… CONTINUE READING
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References

Publications referenced by this paper.
SHOWING 1-10 OF 95 REFERENCES

Prostaglandin E2 production in astrocytes: regulation by cytokines, extracellular ATP, and oxidative agents.

  • Prostaglandins, leukotrienes, and essential fatty acids
  • 2003
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

ERK1/2 in neuronal death

S Subramaniam, K ERKUnsicker, death cell
  • FEBS J 277(1):22–29 14 Mol Neurobiol
  • 2014
VIEW 1 EXCERPT

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