Role of Cytochrome P4502B6 Polymorphisms in Ketamine Metabolism and Clearance

@article{Rao2016RoleOC,
  title={Role of Cytochrome P4502B6 Polymorphisms in Ketamine Metabolism and Clearance},
  author={Lesley K Rao and Alicia M Flaker and Christina Friedel and Evan D. Kharasch},
  journal={Anesthesiology},
  year={2016},
  volume={125},
  pages={1103–1112}
}
Background:At therapeutic concentrations, cytochrome P4502B6 (CYP2B6) is the major P450 isoform catalyzing hepatic ketamine N-demethylation to norketamine in vitro. The CYP2B6 gene is highly polymorphic. The most common variant allele, CYP2B6*6, is associated with diminished hepatic CYP2B6 expression and catalytic activity compared with wild-type CYP2B6*1/*1. CYP2B6.6, the protein encoded by the CYP2B6*6 allele, and liver microsomes from CYP2B6*6 carriers had diminished ketamine metabolism in… 
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