Role of Complement Activation and Mast Cell Degranulation in the Pathogenesis of Rapid Intestinal Ischemia/Reperfusion Injury in Rats

@article{Andoh2001RoleOC,
  title={Role of Complement Activation and Mast Cell Degranulation in the Pathogenesis of Rapid Intestinal Ischemia/Reperfusion Injury in Rats},
  author={A. Andoh and Y. Fujiyama and Y. Araki and T. Kimura and T. Tsujikawa and T. Bamba},
  journal={Digestion},
  year={2001},
  volume={63},
  pages={103 - 107}
}
  • A. Andoh, Y. Fujiyama, +3 authors T. Bamba
  • Published 2001
  • Biology, Medicine
  • Digestion
  • The aim of this study is to define the putative role of complement activation and mucosal mast cell (MMC) degranulation in the pathogenesis of rapid ischemia-reperfusion (I/R) injury. We prepared complement activity-depleted rats by the administration of the anti-complementary agent K-76COONa. To assess the role of MMC degranulation, we used the MMC stabilizer MAR-99 and genetically mast cell-deficient Ws/Ws rats. Autoperfused segments of the jejunum were exposed to 60 min of ischemia, followed… CONTINUE READING
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