Role of Cofilin in Epidermal Growth Factor–Stimulated Actin Polymerization and Lamellipod Protrusion

@article{Chan2000RoleOC,
  title={Role of Cofilin in Epidermal Growth Factor–Stimulated Actin Polymerization and Lamellipod Protrusion},
  author={Amanda Y. Chan and Maryse Bailly and Noureddine Zebda and Jeffrey E Segall and John S Condeelis},
  journal={The Journal of Cell Biology},
  year={2000},
  volume={148},
  pages={531 - 542}
}
Stimulation of metastatic MTLn3 cells with epidermal growth factor (EGF) causes a rapid and transient increase in actin nucleation activity resulting from the appearance of free barbed ends at the extreme leading edge of extending lamellipods. To investigate the role of cofilin in EGF-stimulated actin polymerization and lamellipod extension in MTLn3 cells, we examined in detail the temporal and spatial distribution of cofilin relative to free barbed ends and characterized the actin dynamics by… CONTINUE READING

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