Role of Claspin in regulation of nucleotide excision repair factor DDB2.

@article{PraetoriusIbba2007RoleOC,
  title={Role of Claspin in regulation of nucleotide excision repair factor DDB2.},
  author={Mette Praetorius-Ibba and Qi-En Wang and Gulzar Ahmad Wani and Mohamed El-mahdy and Qianzheng Zhu and Song Qin and Altaf A. Wani},
  journal={DNA repair},
  year={2007},
  volume={6 5},
  pages={578-87}
}
The replication checkpoint protein Claspin is important for maintenance of genomic stability and is required for cells to overcome genotoxic stress. Upon UV-induced DNA damage, Claspin is required for activation of the ATR-mediated DNA damage checkpoint response, leading to arrest of DNA replication and inhibition of cell cycle progression. Located at the DNA replication fork, Claspin is also suggested to monitor replication and sense damage. Our present studies in HeLa cells demonstrate… CONTINUE READING

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