Role of Chemokines in Thyroid Cancer Microenvironment: Is CXCL8 the Main Player?

  title={Role of Chemokines in Thyroid Cancer Microenvironment: Is CXCL8 the Main Player?},
  author={Mario Rotondi and Francesca Coperchini and Francesco Latrofa and Luca Chiovato},
  journal={Frontiers in Endocrinology},
Tumor-related inflammation does influence the biological behavior of neoplastic cells and ultimately the patient’s outcome. With specific regard to thyroid cancer, the issue of tumor-associated inflammation has been extensively studied and recently reviewed. However, the role of chemokines, which play a crucial role in determining the immuno-phenotype of tumor-related inflammation, was not addressed in previous reviews on the topic. Experimental evidence shows that thyroid cancer cells actively… 

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Chemokines, and in particular CXCL10, should no longer be considered as belonging exclusively to basic science, but rather should be used for providing new insights in the clinical management of patients with endocrine autoimmune diseases.

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