Role of Cell Surface Metalloprotease Mt1-Mmp in Epithelial Cell Migration over Laminin-5

Abstract

Laminin-5 (Ln-5) is an extracellular matrix substrate for cell adhesion and migration, which is found in many epithelial basement membranes. Mechanisms eliciting migration on Ln-5 need to be elucidated because of their relevance to tissue remodeling and cancer metastasis. We showed that exogenous addition of activated matrix metalloprotease (MMP) 2… (More)

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@article{Koshikawa2000RoleOC, title={Role of Cell Surface Metalloprotease Mt1-Mmp in Epithelial Cell Migration over Laminin-5}, author={Naohiko Koshikawa and Gianluigi Giannelli and Vincenzo Cirulli and Kaoru Miyazaki and Vito Quaranta}, journal={The Journal of Cell Biology}, year={2000}, volume={148}, pages={615 - 624} }