Role of Cell Membrane-Vector Interactions in Successful Gene Delivery.

@article{Vaidyanathan2016RoleOC,
  title={Role of Cell Membrane-Vector Interactions in Successful Gene Delivery.},
  author={Sriram Vaidyanathan and Bradford G. Orr and Mark M Banaszak Holl},
  journal={Accounts of chemical research},
  year={2016},
  volume={49 8},
  pages={
          1486-93
        }
}
Cationic polymers have been investigated as nonviral vectors for gene delivery due to their favorable safety profile when compared to viral vectors. However, nonviral vectors are limited by poor efficacy in inducing gene expression. The physicochemical properties of cationic polymers enabling successful gene expression have been investigated in order to improve expression efficiency and safety. Studies over the past several years have focused on five possible rate-limiting processes to explain… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-8 OF 8 CITATIONS

tability and binding affinity of DNA / chitosan complexes by olyanion competition ei

Lian Maa, Marc Lavertua, M. Winnikb, Michael D. Buschmanna
  • 2017

References

Publications referenced by this paper.
SHOWING 1-10 OF 69 REFERENCES

Quantitative Measurement of Cationic Polymer Vector and Polymer−pDNA Polyplex Intercalation into the Cell Plasma Membrane

B. G. Orr, M. M. Banaszak Holl
  • ACS Nano 2015,
  • 2015

Similar Papers

Loading similar papers…