Role of Cell Cycle Proteins in CNS Injury

@article{Byrnes2007RoleOC,
  title={Role of Cell Cycle Proteins in CNS Injury},
  author={Kimberly R Byrnes and Alan I. Faden},
  journal={Neurochemical Research},
  year={2007},
  volume={32},
  pages={1799-1807}
}
Following trauma or ischemia to the central nervous system (CNS), there is a marked increase in the expression of cell cycle-related proteins. This up-regulation is associated with apoptosis of post-mitotic cells, including neurons and oligodendrocytes, both in vitro and in vivo. Cell cycle activation also induces proliferation of astrocytes and microglia, contributing to the glial scar and microglial activation with release of inflammatory factors. Treatment with cell cycle inhibitors in CNS… CONTINUE READING
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