Role of Cdk5 in Neuronal Signaling, Plasticity, and Drug Abuse

@article{Bibb2003RoleOC,
  title={Role of Cdk5 in Neuronal Signaling, Plasticity, and Drug Abuse},
  author={James A. Bibb},
  journal={Neurosignals},
  year={2003},
  volume={12},
  pages={191 - 199}
}
  • J. Bibb
  • Published 1 September 2003
  • Biology, Medicine
  • Neurosignals
Functional and structural neuronal plasticity are mediated by a complex network of biochemical signal transduction pathways that control the strength of specific synapses and the formation of new synapses de novo. The neuronal protein kinase Cdk5 has been implicated as being involved in numerous aspects of both functional and structural plasticity through its regulation of signal transduction pathways. In this review the findings of a number of studies are summarized that have advanced our… 
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[Roles of cyclin-dependent kinase 5 in central nervous system development and neurodegenerative diseases].
TLDR
The increasing evidence has showed that Cdk5 is involved in the pathogenesis of many neurodegenerative diseases, such as Alzheimer's disease, Parkinson’s disease, Huntington's disease and amyotrophic lateral sclerosis etc., indicating that C DK5 may be a potential target in the treatment of the neurodegnerative diseases.
Identification of tyrosine hydroxylase as a physiological substrate for Cdk5
TLDR
It is reported that Cdk5 phosphorylates tyrosine hydroxylase (TH), the key enzyme for synthesis of dopamine, and a role for these pathways in the neuroadaptive changes associated with chronic cocaine exposure is suggested.
Striatal dysregulation of Cdk5 alters locomotor responses to cocaine, motor learning, and dendritic morphology
TLDR
It is shown that strong activation of striatal NMDA receptors produced p25, the truncated form of the Cdk5 co-activator p35, which prevented locomotor sensitization to cocaine and attenuated motor coordination and learning in the striatum.
Regulation of Hippocampal and Behavioral Excitability by Cyclin-Dependent Kinase 5
TLDR
Findings indicate that Cdk5 regulates synaptic plasticity, controls neuronal and behavioral stimulus-induced excitability and may be a novel pharmacological target for cognitive and anticonvulsant therapies.
Deregulation of cdk5 in Hippocampal Sclerosis
TLDR
It is suggested that p25 is pathologically increased in HS and that deregulation of cdk5 by p25 might contribute to neuronal death in this condition.
Mechanism of CDK5/p25 binding by CDK inhibitors.
TLDR
An improved crystal form ofCDK5 in complex with p25, a segment of the p35 neuronal activator, is generated and roscovitine stabilized an unusual collapsed conformation of the glycine-rich loop, an important site of CDK regulation.
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