Role of Carbon Monoxide in Host-Gut Microbiome Communication.

@article{Hopper2020RoleOC,
  title={Role of Carbon Monoxide in Host-Gut Microbiome Communication.},
  author={Christopher P. Hopper and Ladie Kimberly C De La Cruz and Kristin V. Lyles and Lauren K. Wareham and Jack A. Gilbert and Zehava Eichenbaum and Marcin Magierowski and Robert K. Poole and Jakob Wollborn and Binghe Wang},
  journal={Chemical reviews},
  year={2020}
}
Nature is full of examples of symbiotic relationships. The critical symbiotic relation between host and mutualistic bacteria is attracting increasing attention to the degree that the gut microbiome is proposed by some as a new organ system. The microbiome exerts its systemic effect through a diverse range of metabolites, which include gaseous molecules such as H2, CO2, NH3, CH4, NO, H2S, and CO. In turn, the human host can influence the microbiome through these gaseous molecules as well in a… 
7 Citations
Rethinking symbiotic metabolism: trophic strategies in the microbiomes of different sponge species
TLDR
It is proposed that sponge symbionts, in particular Acidobacteria, are capable of assimilating carbon through anaplerotic processes and the importance of combining sequencing data with physiology to gain a broader understanding of carbon metabolism within holobionts characterized by highly diverse microbiomes.
Lineage-specific energy and carbon metabolism of sponge symbionts and contributions to the host carbon pool.
TLDR
The molybdenum-binding subunit of dehydrogenase (encoded by coxL) likely evolved to benefit also organoheterotrophs that utilize various organic substrates, and radioisotope assays highlight variability in the relative contributions of photo- and chemoautotrophics to the total carbon pool across different sponge species, emphasizing the importance of validating genomic potential with physiology experimentation.
A Brief History of Carbon Monoxide and Its Therapeutic Origins.
TLDR
Since 2000, the fundamental understanding of CO as a deadly nuisance has undergone a paradigm shift such that CO is now recognized as a neurotransmitter and viable pharmaceutical candidate.
Carbon Monoxide Induced Metabolic Shift in the Carboxydotrophic Parageobacillus thermoglucosidasius DSM 6285
TLDR
It is shown that carbon monoxide (CO) induces metabolic changes linked to distortion of redox balance, evidenced by increased accumulation of organic acids such as acetate and lactate, which suggests that P. thermoglucosidasius survives by expressing several alternative pathways, including conversion of pyruvate to lactate.
Recent advances on endogenous gasotransmitters in inflammatory dermatological disorders
TLDR
A review of the recent progress in the development of effective gas donors and inhibitors is a promising alternative to treat inflammatory dermatological disorders with controllable and precise delivery in the future.
Bioinorganic systems responsive to the diatomic gases O2, NO, and CO: From biological sensors to therapy
Abstract The diatomic molecules, O2, NO and CO, have had a myriad of roles in biology. Due to this, nature has developed many sensing proteins to perceive and respond to changes in the levels of
ItaCORMs: conjugation with a CO-releasing unit greatly enhances the anti-inflammatory activity of itaconates
Endogenous itaconate as well as the gasotransmitter CO have recently been described as powerful anti-inflammatory and immunomodulating agents. However, each of the two agents comes along with a major

References

SHOWING 1-10 OF 529 REFERENCES
Human gut bacteria harbor acquired interbacterial defense systems
TLDR
The data suggest that neutralization of contact-dependent interbacterial antagonism by AID systems helps to shape human gut microbiome ecology, and identifies and validate the protective capability of a recombinase-associated AID subtype that is present broadly in Bacteroidales genomes.
Interplay between the human gut microbiome and host metabolism
TLDR
The authors study the interplay between the microbiome and faecal and blood metabolome, and how the microbiome interacts in the dialogue between these metabolic compartments, identifying a key role for microbial functions and underscoring their relevance for microbiome therapeutic strategies.
Beyond Just Bacteria: Functional Biomes in the Gut Ecosystem Including Virome, Mycobiome, Archaeome and Helminths
TLDR
The recent evidence on the viruses, fungi, archaea, and helminths found in the mammalian gut are reviewed, detailing their interactions with the resident bacterial microbiota and the host, to explore the potential impact of the microbiome on host’s health.
Neuromodulatory effects and targets of the SCFAs and gasotransmitters produced by the human symbiotic microbiota
TLDR
This review is focused on the functional roles of gaseous molecules that perform neuromediator and/or endocrine functions of host intestinal microbial ecology and reveals that interactivity among such modulators/transmitters is a prerequisite for the ongoing dialog between microbial cells and host cells, including neurons.
Carbon monoxide is a poison... to microbes! CO as a bactericidal molecule.
TLDR
Reports that have propelled and challenged the paradoxical use of CO, once viewed as a toxic molecule, now as a host defense molecule agent against microbes are reviewed.
Hydrogen sulfide: an agent of stability at the microbiome-mucosa interface.
TLDR
Hydrogen sulfide plays important roles in modulating epithelial cell-mucus-bacterial interactions in the intestine, contributing to its ability to promote resolution of inflammation and repair of tissue injury.
Synergisms, Discrepancies and Interactions between Hydrogen Sulfide and Carbon Monoxide in the Gastrointestinal and Digestive System Physiology, Pathophysiology and Pharmacology
TLDR
This review was designed to review signaling functions, similarities, dissimilarities and a possible cross-talk between H2S and CO produced endogenously or released from chemical donors, with special emphasis on gastrointestinal digestive system pathologies prevention and treatment.
Metaproteomics of a gutless marine worm and its symbiotic microbial community reveal unusual pathways for carbon and energy use
TLDR
The high expression of proteins involved in pathways for energy and carbon uptake and conservation in the O. algarvensis symbiosis indicates that the oligotrophic nature of its environment exerted a strong selective pressure in shaping these associations.
“Omic” investigations of protozoa and worms for a deeper understanding of the human gut “parasitome”
TLDR
Systems biology–based profiles of the gut “parasitome” under physiological and severe disease conditions can indeed contribute to the control of infectious diseases and offer a new perspective of omics-assisted tropical medicine.
Intestinal gases: influence on gut disorders and the role of dietary manipulations
TLDR
An emerging understanding of the roles of intestinal gases, generated via chemical interactions or the microbial metabolism of dietary substrates, in gut homeostasis and pathophysiology is discussed, highlighting links with dietary intake and new gas profiling methods.
...
1
2
3
4
5
...