Role of Carbon Monoxide in Host-Gut Microbiome Communication.

@article{Hopper2020RoleOC,
  title={Role of Carbon Monoxide in Host-Gut Microbiome Communication.},
  author={Christopher P. Hopper and Ladie Kimberly C De La Cruz and Kristin V. Lyles and Lauren K. Wareham and Jack A. Gilbert and Zehava Eichenbaum and Marcin Magierowski and Robert K. Poole and Jakob Wollborn and Binghe Wang},
  journal={Chemical reviews},
  year={2020}
}
Nature is full of examples of symbiotic relationships. The critical symbiotic relation between host and mutualistic bacteria is attracting increasing attention to the degree that the gut microbiome is proposed by some as a new organ system. The microbiome exerts its systemic effect through a diverse range of metabolites, which include gaseous molecules such as H2, CO2, NH3, CH4, NO, H2S, and CO. In turn, the human host can influence the microbiome through these gaseous molecules as well in a… 

Rethinking symbiotic metabolism: trophic strategies in the microbiomes of different sponge species

It is proposed that sponge symbionts, in particular Acidobacteria, are capable of assimilating carbon through anaplerotic processes and the importance of combining sequencing data with physiology to gain a broader understanding of carbon metabolism within holobionts characterized by highly diverse microbiomes.

Carbon Monoxide Signaling: Examining Its Engagement with Various Molecular Targets in the Context of Binding Affinity, Concentration, and Biologic Response

This review critically examines the literature by quantitatively analyzing the intricate relationships among targets, target affinity for CO, CO level, and the affinity state of carboxyhemoglobin and provides a holistic approach to examining the molecular mechanism(s) of action for CO.

Biome-specific distribution of Ni-containing carbon monoxide dehydrogenases

The findings suggest that while Ni-CODH is a ubiquitous enzyme produced across diverse microbiomes, its distribution in each clade is biased and mainly affected by the distinct composition of microbiomes.

Lineage-specific energy and carbon metabolism of sponge symbionts and contributions to the host carbon pool

The molybdenum-binding subunit of dehydrogenase (encoded by coxL) likely evolved to benefit also organoheterotrophs that utilize various organic substrates, and radioisotope assays highlight variability in the relative contributions of photo- and chemoautotrophics to the total carbon pool across different sponge species, emphasizing the importance of validating genomic potential with physiology experimentation.

Role of Heme Oxygenase in Gastrointestinal Epithelial Cells

The essential roles of HO in the gastrointestinal tract are summarized, focusing on nutrient absorption, protection against cellular stresses, and the maintenance and regulation of tight junction proteins, emphasizing the potential therapeutic implications.

Carbon Monoxide Induced Metabolic Shift in the Carboxydotrophic Parageobacillus thermoglucosidasius DSM 6285

It is shown that carbon monoxide (CO) induces metabolic changes linked to distortion of redox balance, evidenced by increased accumulation of organic acids such as acetate and lactate, which suggests that P. thermoglucosidasius survives by expressing several alternative pathways, including conversion of pyruvate to lactate.

Structural Insights into Microbial One-Carbon Metabolic Enzymes Ni-Fe-S-Dependent Carbon Monoxide Dehydrogenases and Acetyl-CoA Synthases.

Some of the recent advances in understanding the structure and mechanism of CODHs, C ODH/ACSs, and ACDSs, their unusual metallocofactors, and their unique metabolic roles in the human gut and elsewhere are reviewed.

References

SHOWING 1-10 OF 495 REFERENCES

Human gut bacteria harbor acquired interbacterial defense systems

The data suggest that neutralization of contact-dependent interbacterial antagonism by AID systems helps to shape human gut microbiome ecology, and identifies and validate the protective capability of a recombinase-associated AID subtype that is present broadly in Bacteroidales genomes.

Beyond Just Bacteria: Functional Biomes in the Gut Ecosystem Including Virome, Mycobiome, Archaeome and Helminths

The recent evidence on the viruses, fungi, archaea, and helminths found in the mammalian gut are reviewed, detailing their interactions with the resident bacterial microbiota and the host, to explore the potential impact of the microbiome on host’s health.

Interplay between the human gut microbiome and host metabolism

Because of the large inter-person variability in microbiome composition, the results underline the importance of studying gut microbial metabolic pathways rather than focusing purely on taxonomy to find therapeutic and diagnostic targets.

Neuromodulatory effects and targets of the SCFAs and gasotransmitters produced by the human symbiotic microbiota

This review is focused on the functional roles of gaseous molecules that perform neuromediator and/or endocrine functions of host intestinal microbial ecology and reveals that interactivity among such modulators/transmitters is a prerequisite for the ongoing dialog between microbial cells and host cells, including neurons.

Hydrogen sulfide: an agent of stability at the microbiome-mucosa interface.

Hydrogen sulfide plays important roles in modulating epithelial cell-mucus-bacterial interactions in the intestine, contributing to its ability to promote resolution of inflammation and repair of tissue injury.

Metaproteomics of a gutless marine worm and its symbiotic microbial community reveal unusual pathways for carbon and energy use

The high expression of proteins involved in pathways for energy and carbon uptake and conservation in the O. algarvensis symbiosis indicates that the oligotrophic nature of its environment exerted a strong selective pressure in shaping these associations.

Synergisms, Discrepancies and Interactions between Hydrogen Sulfide and Carbon Monoxide in the Gastrointestinal and Digestive System Physiology, Pathophysiology and Pharmacology

This review was designed to review signaling functions, similarities, dissimilarities and a possible cross-talk between H2S and CO produced endogenously or released from chemical donors, with special emphasis on gastrointestinal digestive system pathologies prevention and treatment.

“Omic” investigations of protozoa and worms for a deeper understanding of the human gut “parasitome”

Systems biology–based profiles of the gut “parasitome” under physiological and severe disease conditions can indeed contribute to the control of infectious diseases and offer a new perspective of omics-assisted tropical medicine.

Intestinal gases: influence on gut disorders and the role of dietary manipulations

An emerging understanding of the roles of intestinal gases, generated via chemical interactions or the microbial metabolism of dietary substrates, in gut homeostasis and pathophysiology is discussed, highlighting links with dietary intake and new gas profiling methods.
...