Role of Capsule and O Antigen in the Virulence of Uropathogenic Escherichia coli

@inproceedings{Sarkar2014RoleOC,
  title={Role of Capsule and O Antigen in the Virulence of Uropathogenic Escherichia coli},
  author={Sohinee Sarkar and Glen C Ulett and Makrina Totsika and Minh-Duy Phan and Mark A Schembri},
  booktitle={PloS one},
  year={2014}
}
Urinary tract infection (UTI) is one of the most common bacterial infections in humans, with uropathogenic Escherichia coli (UPEC) the leading causative organism. UPEC has a number of virulence factors that enable it to overcome host defenses within the urinary tract and establish infection. The O antigen and the capsular polysaccharide are two such factors that provide a survival advantage to UPEC. Here we describe the application of the rpsL counter selection system to construct capsule (kpsD… CONTINUE READING
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