Role of Cannabinoids in the Development of Fatty Liver (Steatosis)

@article{Purohit2010RoleOC,
  title={Role of Cannabinoids in the Development of Fatty Liver (Steatosis)},
  author={Vishnudutt Purohit and Rao S. Rapaka and David Shurtleff},
  journal={The AAPS Journal},
  year={2010},
  volume={12},
  pages={233-237}
}
Emerging evidence suggests that cannabinoids play an important role in the modulation of fatty liver, which appears to be mediated via activation of cannabinoid receptors. Steatogenic agents such as ethanol and high-fat diet can upregulate the activity of cannabinoid 1 (CB1) receptors via increasing synthesis of endocannabinoids, 2-arachidonoylglycerol, and anandamide. CB1 receptors can also be upregulated by obesity. CB1 receptor activation results in upregulation of lipogenic transcription… CONTINUE READING