Role of Cannabinoids in Pain Management

  title={Role of Cannabinoids in Pain Management},
  author={Ethan B. Russo and Andrea G. Hohmann},
It is a curious fact that we owe a great deal of our insight into pharmacological treatment of pain to the plant world. Willow bark from Salix spp. led to development of aspirin and eventual elucidation of the analgesic effects of prostaglandins and their role in inflammation. The opium poppy (Papaver somniferum) provided the prototypic narcotic analgesic morphine, the first alkaloid discovered, and stimulated the much later discovery of the endorphin and enkephalin systems. Similarly, the… 
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The endocannabinoid system and pain.
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Prostaglandins and cannabis. II. Inhibition of biosynthesis by the naturally occurring cannabinoids.
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