Role of Candida albicans transcription factor Upc2p in drug resistance and sterol metabolism.

@article{Silver2004RoleOC,
  title={Role of Candida albicans transcription factor Upc2p in drug resistance and sterol metabolism.},
  author={Peter M Silver and Brian G G Oliver and Theodore C. White},
  journal={Eukaryotic cell},
  year={2004},
  volume={3 6},
  pages={1391-7}
}
In Candida albicans, drug resistance to clinically important antifungal drugs may be regulated through the action of transcription factors in a manner that may or may not be similar to regulation in Saccharomyces cerevisiae. A search of the C. albicans genome identified a single homolog of the S. cerevisiae transcription factor genes UPC2 (ScUPC2) and ECM22 (ScECM22) that have been associated with regulation of ergosterol biosynthesis. Sequence analysis of this C. albicans UPC2 (CaUPC2) gene… CONTINUE READING

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