Role of CaVbeta subunits, and lack of functional reserve, in protein kinase A modulation of cardiac CaV1.2 channels.

@article{Miriyala2008RoleOC,
  title={Role of CaVbeta subunits, and lack of functional reserve, in protein kinase A modulation of cardiac CaV1.2 channels.},
  author={Jayalakshmi Miriyala and Trang Thi Nhu Nguyen and David T. Yue and Henry M Colecraft},
  journal={Circulation research},
  year={2008},
  volume={102 7},
  pages={e54-64}
}
Protein kinase A (PKA)-mediated enhancement of L-type calcium currents (I(Ca,L)) is essential for sympathetic regulation of the heartbeat and is the classic example of channel regulation by phosphorylation, and its loss is a common hallmark of heart failure. Mechanistic understanding of how distinct Ca(V) channel subunits contribute to PKA modulation of I… CONTINUE READING