Role of CaM kinase II and ERK activation in thrombin-induced endothelial cell barrier dysfunction.

@article{Borbiev2003RoleOC,
  title={Role of CaM kinase II and ERK activation in thrombin-induced endothelial cell barrier dysfunction.},
  author={Talaibek Borbiev and Alexander Dimitrievich Verin and Anna A Birukova and Feng Liu and Michael T. Crow and Joe G. N. Garcia},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2003},
  volume={285 1},
  pages={L43-54}
}
We have previously shown that thrombin-induced endothelial cell barrier dysfunction involves cytoskeletal rearrangement and contraction, and we have elucidated the important role of endothelial cell myosin light chain kinase and the actin- and myosin-binding protein caldesmon. We evaluated the contribution of calmodulin (CaM) kinase II and extracellular signal-regulated kinase (ERK) activation in thrombin-mediated bovine pulmonary artery endothelial cell contraction and barrier dysfunction… CONTINUE READING

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