Role of Ca2+ in pyruvate dehydrogenase interconversion in brain mitochondria and synaptosomes.

@article{Hansford1985RoleOC,
  title={Role of Ca2+ in pyruvate dehydrogenase interconversion in brain mitochondria and synaptosomes.},
  author={Richard G N Hansford and Francesc Castro},
  journal={The Biochemical journal},
  year={1985},
  volume={227 1},
  pages={129-36}
}
The steady-state content of active (dephospho) pyruvate dehydrogenase (PDHA) of suspensions of coupled rat brain mitochondria oxidizing succinate was found to be markedly increased with increasing free Ca2+ ion concentration of the medium, with a half-maximal effect at 10(-6.43) M Ca2+. Other ions were present in these studies at concentrations appropriate for the cytosol. Depolarization of the plasma membrane of synaptosomes caused an increase in the steady-state content of PDHA, with… CONTINUE READING
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