Role of Ca2+ -dependent and Ca2+ -sensitive mechanisms in sphingosine 1-phosphate-induced constriction of isolated porcine retinal arterioles in vitro.

@article{Kamiya2014RoleOC,
  title={Role of Ca2+ -dependent and Ca2+ -sensitive mechanisms in sphingosine 1-phosphate-induced constriction of isolated porcine retinal arterioles in vitro.},
  author={Takayuki Kamiya and Taiji Nagaoka and Tsuneaki Omae and Takafumi Yoshioka and Shinji Ono and Ichiro Tanano and Akitoshi Yoshida},
  journal={Experimental eye research},
  year={2014},
  volume={121},
  pages={94-101}
}
Although sphingosine 1-phosphate (S1P), a bioactive lipid derived from activated platelets, has a variety of physiologic effects on vessels, no reports have described the effect of S1P on the retinal circulation. We examined the effect and underlying mechanism of the vasomotor action of S1P on porcine retinal arterioles. The porcine retinal arterioles were isolated, cannulated, and pressurized without flow for in vitro study. S1P-induced diameter changes were recorded using videomicroscopic… CONTINUE READING