Role of Ca2+/CaMK II in Ca(2+)-induced K+ channel inhibition in rat CCD principal cell.

@article{Kubokawa1995RoleOC,
  title={Role of Ca2+/CaMK II in Ca(2+)-induced K+ channel inhibition in rat CCD principal cell.},
  author={Manabu Kubokawa and Wenhui Wang and Carmel M. McNicholas and Gerhard Giebisch},
  journal={The American journal of physiology},
  year={1995},
  volume={268 2 Pt 2},
  pages={F211-9}
}
The apical low-conductance K+ channel of rat cortical collecting duct (CCD) is inhibited by increased intracellular Ca2+ concentrations. This effect has been shown to be mediated at least in part by activation of protein kinase C (PKC). In the present study, we used the patch-clamp technique to examine the role of Ca2+/calmodulin-dependent protein kinase II (CaMK II) in mediating the Ca(2+)-induced inhibitory effect. In cell-attached patches of principal cells of rat tubules, clamping of… CONTINUE READING
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