Role of Ca(2+)-calmodulin dependent phospholamban phosphorylation on the relaxant effect of beta-adrenergic agonists.

@article{Vittone1993RoleOC,
  title={Role of Ca(2+)-calmodulin dependent phospholamban phosphorylation on the relaxant effect of beta-adrenergic agonists.},
  author={Leticia Vittone and C Mundi{\~n}a and Gladys E Chiappe de Cingolani and Alicia R. Mattiazzi},
  journal={Molecular and cellular biochemistry},
  year={1993},
  volume={124 1},
  pages={33-42}
}
The role of the Ca(2+)-calmodulin dependent pathway of phospholamban phosphorylation on the relaxant effect of beta-adrenergic agonists was studied in isolated perfused rat heart. Administration of the calmodulin antagonist W7 or lowering [Ca]o from 1.35 mM (control) to 0.25 mM, were used as experimental tools to inhibit the Ca(2+)-calmodulin dependent… CONTINUE READING