Role of CYP2E1 in diethylnitrosamine-induced hepatocarcinogenesis in vivo.

@article{Kang2007RoleOC,
  title={Role of CYP2E1 in diethylnitrosamine-induced hepatocarcinogenesis in vivo.},
  author={Jin Seok Kang and Hideki Wanibuchi and Keiichirou Morimura and Frank J. Gonzalez and Shoji Fukushima},
  journal={Cancer research},
  year={2007},
  volume={67 23},
  pages={11141-6}
}
CYP2E1 metabolizes many low-molecular weight toxins and carcinogens. Some in vitro experiments suggest that CYP2E1 may be involved in the metabolic activation of diethylnitrosamine. However, there has been no direct evidence demonstrating a role for CYP2E1 in diethylnitrosamine-mediated carcinogenesis in vivo. To clarify this, we carried out a diethylnitrosamine-induced hepatocarcinogenesis experiment using Cyp2e1-null mice. Male 14-day-old wild-type and Cyp2e1-null mice were treated with… CONTINUE READING
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