Role of CYP2C9 and CYP2C19 polymorphisms in patients with atherosclerosis.

  title={Role of CYP2C9 and CYP2C19 polymorphisms in patients with atherosclerosis.},
  author={Bahadır Ercan and Lokman Ayaz and Demet Çiçek and Lulufer Tamer},
  journal={Cell biochemistry and function},
  volume={26 3},
The arachidonic acid metabolizing CYP enzymes with prominent roles in vascular regulation are epoxygenases of the two gene family which generate epoxyeicosatrienoic acids. Carriers of CYP2C9 mutant alleles exhibit a diminished CYP2C9 metabolic capacity leading to decreased endothelium-derived hyperpolarizing factors (EDHF) synthesis and an increased risk for atherosclerosis. We investigated whether the polymorphisms of CYP2C9/19 are related with atherosclerosis. We examined 108 patients having… CONTINUE READING


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