Role of CXCR3-induced donor T-cell migration in acute GVHD.

  title={Role of CXCR3-induced donor T-cell migration in acute GVHD.},
  author={Ulrich A. Duffner and Bao Shi Lu and Gerhard C. Hildebrandt and Takanori Teshima and Debra L. Williams and Pavan Reddy and Rainer Ordemann and Shawn G. Clouthier and Kathy Lowler and Chen Liu and Craig Gerard and Kenneth R. Cooke and James L. M. Ferrara},
  journal={Experimental hematology},
  volume={31 10},
OBJECTIVE The chemokine receptor CXCR3 has an important role in the migration of effector T cells. To investigate the role of CXCR3 on donor cells in acute graft vs host disease (GVHD) we used a well-defined experimental bone marrow transplantation (BMT) model where acute GVHD is mediated by donor CD8(+) T cells against minor histocompatibility antigens. METHODS; Lethally irradiated C3H.SW recipients were transplanted from either wild-type B6 or CXCR3(-/-) B6 donors. Donor T-cell expansion was… CONTINUE READING
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