Role of CXCR3/CXCL10 Axis in Immune Cell Recruitment into the Small Intestine in Celiac Disease

@inproceedings{Bondar2014RoleOC,
  title={Role of CXCR3/CXCL10 Axis in Immune Cell Recruitment into the Small Intestine in Celiac Disease},
  author={Constanza Bondar and Romina E Araya and Luciana Guzm{\'a}n and Eduardo Cueto R{\'u}a and N{\'e}stor Chopita and Fernando G. Chirdo},
  booktitle={PloS one},
  year={2014}
}
Lymphocytic infiltration in the lamina propria (LP), which is primarily composed of CD4(+) Th1 cells and plasma cells, and increased numbers of intraepithelial lymphocytes (IELs), is a characteristic finding in active celiac disease (CD). Signals for this selective cell recruitment have not been fully established. CXCR3 and its ligands, particularly CXCL10, have been suggested to be one of the most relevant pathways in the attraction of cells into inflamed tissues. In addition, CXCR3 is… CONTINUE READING
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