Role of CX3C-chemokine CX3C-L/fractalkine expression in a model of slowly progressive renal failure.

@article{Koziolek2010RoleOC,
  title={Role of CX3C-chemokine CX3C-L/fractalkine expression in a model of slowly progressive renal failure.},
  author={M. Koziolek and G. M{\"u}ller and A. Zapf and D. Patschan and H. Schmid and C. Cohen and S. Koschnick and R. Vasko and C. Bramlage and F. Strutz},
  journal={Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association},
  year={2010},
  volume={25 3},
  pages={
          684-98
        }
}
  • M. Koziolek, G. Müller, +7 authors F. Strutz
  • Published 2010
  • Medicine
  • Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
BACKGROUND The chemokine/chemokine receptor pair CX(3)C-L/CX(3)C-R is suspected to play a role in renal fibrogenesis. The aim of this study was to investigate their function in an animal model of slowly progressive chronic renal failure. METHODS Functional data were analysed in folic acid nephropathy (FAN) at different time points (up to day 142 after induction). Immunostaining for CX(3)C-L, CD3, S100A4, collagen type I, fibronectin, alpha-smooth muscle actin, Tamm-horsfall protein, aquaporin… Expand
Fractalkine mediates lymphocyte inflammation and tubulointerstitial lesions by modifying the Treg/Th17 balance in lupus-prone MRL/lpr mice.
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