Role of CRF receptor signaling in stress vulnerability, anxiety, and depression.

@article{Hauger2009RoleOC,
  title={Role of CRF receptor signaling in stress vulnerability, anxiety, and depression.},
  author={Richard L. Hauger and Victoria B Risbrough and Robert H. Oakley and Jes{\'u}s Alberto Olivares-Reyes and Frank M. Dautzenberg},
  journal={Annals of the New York Academy of Sciences},
  year={2009},
  volume={1179},
  pages={120-43}
}
Markers of hyperactive central corticotropin releasing factor (CRF) systems and CRF-related single nucleotide polymorphisms (SNPs) have been identified in patients with anxiety and depressive disorders. Designing more effective antagonists may now be guided by data showing that small molecules bind to transmembrane domains. Specifically, CRF(1) receptor antagonists have been developed as novel anxiolytic and antidepressant treatments. Because CRF(1) receptors become rapidly desensitized by G… CONTINUE READING