Role of CRE-Binding Protein (CREB) in Aromatase Expression in Breast Adipose

@article{Sofi2003RoleOC,
  title={Role of CRE-Binding Protein (CREB) in Aromatase Expression in Breast Adipose},
  author={Mariam Sofi and Morag J. Young and Theodora Papamakarios and Evan R. Simpson and Colin Clyne},
  journal={Breast Cancer Research and Treatment},
  year={2003},
  volume={79},
  pages={399-407}
}
Estrogen biosynthesis from C19 steroids is catalyzed by aromatase cytochrome P450. Aromatase is expressed in breast adipose tissue through the use of a distal, cytokine-responsive promoter (promoter I.4). Breast tumors, however, secrete soluble factors that over-stimulate aromatase expression through an alternative proximal cAMP-responsive promoter, promoter II. We have mapped the cAMP-responsive regions of promoter II by transient transfection of 3T3-L1 preadipocytes with aromatase promoter II… CONTINUE READING

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