Role of CNS transporters in the pharmacotherapy of HIV-1 associated neurological disorders.

@article{Ashraf2014RoleOC,
  title={Role of CNS transporters in the pharmacotherapy of HIV-1 associated neurological disorders.},
  author={Tamima Ashraf and Kevin R Robillard and Gary N Y Chan and Reina Bendayan},
  journal={Current pharmaceutical design},
  year={2014},
  volume={20 10},
  pages={
          1543-63
        }
}
Membrane-associated drug transporters are important determinants of antiretroviral drug disposition in the central nervous system during HIV-1 infection. A number of influx and efflux transport proteins expressed at the blood-brain barrier, blood-cerebrospinal fluid barrier and in brain parenchyma cellular compartments (i.e., astrocytes, microglia) have been implicated in the traffic of many antiretroviral drugs into and out of the brain. In particular, members of the ATP-binding cassette… CONTINUE READING

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