Role of CL-100, a dual specificity phosphatase, in thrombin-induced endothelial cell activation.

@article{Chandrasekharan2004RoleOC,
  title={Role of CL-100, a dual specificity phosphatase, in thrombin-induced endothelial cell activation.},
  author={Unni M. Chandrasekharan and Lin Yang and Alicia Walters and Philip H Howe and Paul E. Dicorleto},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 45},
  pages={46678-85}
}
Using a cDNA microarray screening approach, we have identified seven novel thrombin-responsive genes in human umbilical vein endothelial cells that were verifiable by Northern blot analysis. Among them CL-100, a dual-specificity phosphatase also known as MAP kinase phosphatase-1 (MKP-1), showed greatest induction by thrombin. Steady-state levels of CL-100 mRNA induction by thrombin peaked at 1 h and declined rapidly (t1/2 approximately 45 min). Induction by thrombin was protease-activated… CONTINUE READING

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