Role of CD8a1 and CD8a2 dendritic cells in the induction of primary immune responses in vivo


Data from adoptive transfer of mature dendritic cells (DC) indicate that they are responsible for the induction of primary immunity. Two subclasses of DC have been recently identified in spleen that differ in their phenotype and in certain regulatory features. In vitro, both subsets have the capacity to activate naive T cells, although CD8a1 DC have been… (More)


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