Role of CD44 in tumour progression and strategies for targeting.

  title={Role of CD44 in tumour progression and strategies for targeting.},
  author={Lalit Mohan Negi and Sushama Talegaonkar and Manu Jaggi and Farhan Jalees Ahmad and Zeenat Iqbal and Roop Kishan Khar},
  journal={Journal of drug targeting},
  volume={20 7},
CD44 or hyaluronan receptor is a transmembrane receptor associated with aggressive tumour growth, proliferation, and metastasis. In normal physiology, this receptor has a crucial role in cell adhesion, inflammation, and repair processes. However, many tumour cells over-express this receptor and abuse it to become progressive and perpetual units. The article comments from common functioning of the CD44 receptor, to its diabolic multi-dimensional effects in promotion of malignant cells. It also… CONTINUE READING
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