Corpus ID: 28240346

Role of CD44 in the development of natural killer cells from precursors in long-term cultures of mouse bone marrow.

@article{Delfino1994RoleOC,
  title={Role of CD44 in the development of natural killer cells from precursors in long-term cultures of mouse bone marrow.},
  author={D. Delfino and K. Patrene and A. Deleo and R. Deleo and R. Herberman and S. Boggs},
  journal={Journal of immunology},
  year={1994},
  volume={152 11},
  pages={
          5171-9
        }
}
The role of the adhesion molecule CD44 in the development of NK cells was analyzed in a mouse long-term bone marrow culture system. After 4 wk of culture (day 0), recombinant human IL-2 was added and 13 days later the cells generated were shown to have substantial cytotoxic activity against YAC-1 and to be enriched for NK cells, as assessed for NK-1.1 phenotype by flow cytometric analysis. Physical separation between stroma and precursors partially inhibited proliferation and, consequently, a… Expand
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