Role of CD4 receptor down-regulation during HIV-1 infection.

  title={Role of CD4 receptor down-regulation during HIV-1 infection.},
  author={Karine L{\'e}vesque and Andr{\'e}s Finzi and J. C. Binette and {\'E}ric A Cohen},
  journal={Current HIV research},
  volume={2 1},
Human immunodeficiency virus has evolved several redundant mechanisms to remove its receptor, the CD4 molecule, from the cell surface. Indeed, HIV-1 encodes three proteins, Nef, Vpu and Env, that have a profound effect on CD4 trafficking and catabolism. Given this functional convergence, it is believed that cell surface CD4 regulation constitutes an… CONTINUE READING