Role of CD4+CD45RA+ T cells in the development of autoimmune diabetes in the non-obese diabetic (NOD) mouse.

@article{Semp1993RoleOC,
  title={Role of CD4+CD45RA+ T cells in the development of autoimmune diabetes in the non-obese diabetic (NOD) mouse.},
  author={Pascal Semp{\'e} and Sophie Ezine and Jacqueline Marvel and Pierre Bedossa and Michelle D Richard and J. F. Bach and Christian Boitard},
  journal={International immunology},
  year={1993},
  volume={5 5},
  pages={479-89}
}
The non-obese diabetic (NOD) mouse spontaneously develops a T cell-mediated autoimmune disease, sharing many features with human insulin-dependent diabetes mellitus (IDDM), leading to insulin-secreting beta cell destruction. The role of CD4+ T cells has been evidenced at two levels. First, CD4+ T cells from diabetic animals are required to transfer diabetes to non-diabetic recipients in conjunction with CD8+ effector T cells. Second, suppressive CD4+ T cells have been characterized in non… CONTINUE READING