Role of CD38 in cell-cell interactions under conditions of endothelial dysfunction

  title={Role of CD38 in cell-cell interactions under conditions of endothelial dysfunction},
  author={A. I. Inzhutova and Alla B. Salmina and Marina M. Petrova and A. A. Larionov},
  journal={Bulletin of Experimental Biology and Medicine},
We studied the role of receptor/ectoenzyme CD38 in the formation of endothelial damage and pathogenesis of endothelial dysfunction. CD38 was located in sites of protrusion of the outer cytoplasmic membrane. The majority of CD38+ accumulation sites coincided with the protrusion pole, while in some cells expression of CD38 was spread along the entire cell membrane surface or located on the pole opposite to the protrusion. We hypothesized that these states reflect the processes of rafting and… 

Theory of Intercellular Communication in the Development of Endothelial Dysfunction

Hyperactivation of endothelial cells and constant stimulation by the lymphocytes and microparticles trigger programmed cell death resulting in exfoliation of the endothelial cell.

Endothelial dysfunction and repair in Alzheimer-type neurodegeneration: neuronal and glial control.

The properties of the brain endothelium that contribute to its specific functions in the central nervous system are described, and how endothelial-neuronal-glial cell interactions are compromised in the pathogenesis of AD are described.

Alteration of Neuron-Glia Interactions in Neurodegeneration: Molecular Biomarkers and Therapeutic Strategy

Alignment of neuron-astrocyte metabolic coupling provides tight interactions between the activated neuronal cells consuming lactate and lactate-producing astrocytes in the context of pathogenesis of neurodegenerative disorders.

Immunological studies on anca-associated vasculitis with special reference to T cell activation

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Human CD38 (ADP-ribosyl cyclase) is a counter-receptor of CD31, an Ig superfamily member.

The results suggest that the interplay between CD38 and its ligand CD31 is an important step in the regulation of cell life and of the migration of leukocytes (and CD38+ cancer cells) through the endothelial cell wall.

Circulating Endothelial Cells: Realities and Promises in Vascular Disorders

An antibody against the endothelial molecule CD126 (S-Endol) is produced and an original and sensitive immunomagnetic separation assay is developed to demonstrate elevated number of CECs in clinical diseases linked with vascular injury like heart catheterization, sickle cell anemia, bacterial infection, thromboticThrombocytopenic purpura or acute coronary syndromes.

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The results suggest that the activation signals transduced by CD38 in NK cells elicit relevant cellular events that are similar to those elicited via CD16 and possibly rely on common signaling pathways.

CD38 Signaling in T Cells Is Initiated within a Subset of Membrane Rafts Containing Lck and the CD3-ζ Subunit of the T Cell Antigen Receptor*

Findings provide the first evidence that CD38 operates in two functionally distinct microdomains of the plasma membrane, possibly by facilitating critical associations within other raft subsets, for example, LAT rafts via its capacity to interact with Lck and CD3-ζ.

The immunological synapse.

The current model is that signaling and formation of the immunological synapse are tightly interwoven in mature T cells and this model is extended to natural killer cell activation, where the inhibitory NK synapse provides a striking example in which inhibition of signaling leaves the synapse in its nascent, inverted state.

Human CD38 and related molecules

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