Role of CD28 in acute graft-versus-host disease.

@article{Yu1998RoleOC,
  title={Role of CD28 in acute graft-versus-host disease.},
  author={Xuesong Yu and Paul J Martin and Claudio Anasetti},
  journal={Blood},
  year={1998},
  volume={92 8},
  pages={
          2963-70
        }
}
Because CD28-mediated T-cell costimulation has a pivotal role in the initiation and maintenance of T-cell responses, we tested the hypothesis that CD28 is critical for the development of graft-versus-host disease (GVHD). We compared the in vivo effects of CD28(-/-) T cells transplanted from B6 donor with the CD28 gene deleted by homologous recombination with those of CD28(+/+) T cells transplanted from wild-type C57BL/6 (B6) donor. Fifty million CD28(-/-) or CD28(+/+) splenocytes from B6 mice… CONTINUE READING

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