Role of CD14 molecules in internalization of Actinobacillus actinomycetemcomitans by macrophages and subsequent induction of apoptosis.

@article{Muro1997RoleOC,
  title={Role of CD14 molecules in internalization of Actinobacillus actinomycetemcomitans by macrophages and subsequent induction of apoptosis.},
  author={Masami Muro and Takeyoshi Koseki and Sumio Akifusa and Seiichi Kato and Yusuke Kowashi and Yoshinobu Ohsaki and Kenji Yamato and Motohiro Nishijima and Tatsuji Nishihara},
  journal={Infection and immunity},
  year={1997},
  volume={65 4},
  pages={1147-51}
}
We report the evidence for apoptosis in J774.1 cells by the periodontopathic bacterium Actinobacillus actinomycetemcomitans, suggesting that the ability of A. actinomycetemcomitans to promote apoptosis might be important in the initiation and development of periodontitis. In this study, we examined the role of macrophage CD14, anchored by a glycerophosphatidylinositol tail, in the induction of apoptosis by A. actinomycetemcomitans infection by using the parent J774.1 cells and CD14-defective… CONTINUE READING

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