Role of CCR5 in infection of primary macrophages and lymphocytes by macrophage-tropic strains of human immunodeficiency virus: resistance to patient-derived and prototype isolates resulting from the delta ccr5 mutation.

@article{Rana1997RoleOC,
  title={Role of CCR5 in infection of primary macrophages and lymphocytes by macrophage-tropic strains of human immunodeficiency virus: resistance to patient-derived and prototype isolates resulting from the delta ccr5 mutation.},
  author={Sameer Rana and G Besson and D. G. Cook and Joseph Rucker and Robert J. Smyth and Yanjie Yi and Julie Davis Turner and Haiwei Henry Guo and Jiang Du and Stephen C. Peiper and Ehud Lavi and Michel Samson and Fr{\'e}d{\'e}rick Libert and Corinne Liesnard and G. Vassart and Robert W. Doms and Marc Parmentier and Ronald G. Collman},
  journal={Journal of virology},
  year={1997},
  volume={71 4},
  pages={3219-27}
}
The alpha-chemokine receptor fusin (CXCR-4) and beta-chemokine receptor CCR5 serve as entry cofactors for T-cell (T)-tropic and macrophage (M)-tropic human immunodeficiency virus type 1 (HIV-1) strains, respectively, when expressed with CD4 in otherwise nonpermissive cells. Some M-tropic and dual-tropic strains can also utilize other beta-chemokine receptors, such as CCR2b and CCR3. A mutation of CCR5 (delta ccr5) was recently found to be common in certain populations and appears to confer… CONTINUE READING