Role of CCR5 in IFN-gamma-induced and cigarette smoke-induced emphysema.

  title={Role of CCR5 in IFN-gamma-induced and cigarette smoke-induced emphysema.},
  author={Bing Ma and Min-Jong Kang and Chun Geun Lee and Svetlana P Chapoval and Wei Liu and Qingsheng Chen and Anthony J Coyle and Jose M. Lora and Dominic Picarella and Robert J Homer and Jack A Elias},
  journal={The Journal of clinical investigation},
  volume={115 12},
Th1 inflammation and remodeling characterized by tissue destruction frequently coexist in human diseases. To further understand the mechanisms of these responses, we defined the role(s) of CCR5 in the pathogenesis of IFN-gamma-induced inflammation and remodeling in a murine emphysema model. IFN-gamma was a potent stimulator of the CCR5 ligands macrophage inflammatory protein-1alpha/CCL-3 (MIP-1alpha/CCL-3), MIP-1beta/CCL-4, and RANTES/CCL-5, among others. Antibody neutralization or null… CONTINUE READING


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