Role of CC chemokines in skeletal muscle functional restoration after injury.

  title={Role of CC chemokines in skeletal muscle functional restoration after injury.},
  author={Gordon L Warren and Laura O'farrell and Mukesh Summan and Tracy Hulderman and Dawn Mishra and Michael I. Luster and William A. Kuziel and Petia Simeonova},
  journal={American journal of physiology. Cell physiology},
  volume={286 5},
The purpose of this study was to determine whether certain chemokines, which are highly expressed in injured skeletal muscle, are involved in the repair and functional recovery of the muscle after traumatic injury. In wild-type control mice, mRNA transcripts of macrophage inflammatory protein (MIP)-1alpha, MIP-1beta, and monocyte chemoattractant protein (MCP)-1 as well as their major receptors, CCR5 and CCR2, increased after freeze injury and gradually returned to control (uninjured) levels by… CONTINUE READING


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