Role of CC chemokines in skeletal muscle functional restoration after injury.

  title={Role of CC chemokines in skeletal muscle functional restoration after injury.},
  author={G. L. Warren and L. O'farrell and M. Summan and Tracy Hulderman and Dawn Mishra and M. Luster and W. Kuziel and P. Simeonova},
  journal={American journal of physiology. Cell physiology},
  volume={286 5},
  • G. L. Warren, L. O'farrell, +5 authors P. Simeonova
  • Published 2004
  • Biology, Medicine
  • American journal of physiology. Cell physiology
  • The purpose of this study was to determine whether certain chemokines, which are highly expressed in injured skeletal muscle, are involved in the repair and functional recovery of the muscle after traumatic injury. In wild-type control mice, mRNA transcripts of macrophage inflammatory protein (MIP)-1alpha, MIP-1beta, and monocyte chemoattractant protein (MCP)-1 as well as their major receptors, CCR5 and CCR2, increased after freeze injury and gradually returned to control (uninjured) levels by… CONTINUE READING
    138 Citations
    Fat accumulation with altered inflammation and regeneration in skeletal muscle of CCR2-/- mice following ischemic injury.
    • 130
    Chemokine receptor CCR2 involvement in skeletal muscle regeneration
    • 144
    MCP-1 parallels inflammatory and regenerative responses in ischemic muscle.
    • 55
    CC family chemokines directly regulate myoblast responses to skeletal muscle injury
    • 100
    • Highly Influenced
    CXCL10 increases in human skeletal muscle following damage but is not necessary for muscle regeneration
    • 3
    CX3CL1--a macrophage chemoattractant induced by a single bout of exercise in human skeletal muscle.
    • 24
    Time course of chemokine expression and leukocyte infiltration after acute skeletal muscle injury in mice
    • 12
    • Highly Influenced
    • PDF
    Macrophages and skeletal muscle regeneration: a clodronate-containing liposome depletion study.
    • 232
    • PDF


    MIP-1alpha as a critical macrophage chemoattractant in murine wound repair.
    • 265
    • PDF
    Monocyte recruitment and myelin removal are delayed following spinal cord injury in mice with CCR2 chemokine receptor deletion
    • 103
    The chemokine receptor CCR2 is involved in macrophage recruitment to the injured peripheral nervous system
    • 153
    Wound healing in MIP-1alpha(-/-) and MCP-1(-/-) mice.
    • 125
    Physiological role of tumor necrosis factor α in traumatic muscle injury
    • 234
    Expression profiling of cytokines and related genes in regenerating skeletal muscle after cardiotoxin injection: a role for osteopontin.
    • 131
    Severe reduction in leukocyte adhesion and monocyte extravasation in mice deficient in CC chemokine receptor 2.
    • 690
    • PDF
    Targeting monocyte chemoattractant protein-1 signalling in disease
    • 126
    Significant Involvement of CCL2 (MCP‐1) in Inflammatory Disorders of the Lung
    • 201
    Inflammatory mediators and skeletal muscle injury: a DNA microarray analysis.
    • M. Summan, M. McKinstry, +5 authors P. Simeonova
    • Biology, Medicine
    • Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research
    • 2003
    • 63