Role of CC chemokine receptor 2 in bone marrow cells in the recruitment of macrophages into obese adipose tissue.

@article{Ito2008RoleOC,
  title={Role of CC chemokine receptor 2 in bone marrow cells in the recruitment of macrophages into obese adipose tissue.},
  author={Ayaka Ito and Takayoshi Suganami and Akira Yamauchi and Mikako Degawa-Yamauchi and Miyako Tanaka and Ryuji Kouyama and Yuko Kobayashi and Nao Nitta and Kazuki Yasuda and Yukio Hirata and William A. Kuziel and Motohiro Takeya and Shiro Kanegasaki and Yasutomi Kamei and Yoshihiro Ogawa},
  journal={The Journal of biological chemistry},
  year={2008},
  volume={283 51},
  pages={35715-23}
}
The MCP-1 (monocyte chemoattractant protein-1)/CCR2 (CC motif chemokine receptor-2) pathway may play a role in macrophage infiltration into obese adipose tissue. Here we investigated the role of CCR2 in the recruitment of bone marrow-derived macrophages into obese adipose tissue in vitro and in vivo. Using the TAXIScan device, which can measure quantitatively the directionality and velocity of cell migration at time lapse intervals in vitro, we demonstrated that bone marrow cells (BMCs) from… CONTINUE READING

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