Role of C-reactive protein in atherogenesis: can the apolipoprotein E knockout mouse provide the answer?

@article{Reifenberg2005RoleOC,
  title={Role of C-reactive protein in atherogenesis: can the apolipoprotein E knockout mouse provide the answer?},
  author={Kurt Reifenberg and Hans-Anton Lehr and Daniela Baskal and Elena Wiese and S. C. Sch{\"a}fer and Steven Black and David Samols and Michael Torzewski and Karl J. Lackner and Matthias Husmann and Maria Blettner and Sucharit Bhakdi},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2005},
  volume={25 8},
  pages={1641-6}
}
OBJECTIVE Human C-reactive protein (CRP) was reported to accelerate atherosclerotic lesion development in male but not in female apolipoprotein E (apoE) knockout mice. Here, mice expressing rabbit CRP (rbCRP) were crossbred onto apoE knockout animals, and the effect on atherogenesis was studied. METHODS AND RESULTS Hemolytic complement activity could not be detected in apoE knockout mice. Furthermore, in contrast to human complement, neither rabbit nor human CRP complexed to modified low… CONTINUE READING

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